We hope this will solve our problems and he can live a healthy and happy life. They want to test him for the MDR gene, put him on fluids and I have to take him in tomorrow for more fluids but he is not improving. DO NOT give this poison to your pets. Hes very lethargic and constant vomiting! This time he just kept collapsing, bloated appearing, vomit, and diarrhea, and hiding with his face down and nose in carpet. Went to a different vet, within minutes he found a large mass on my Poms abdomen. He also had a seizure that lasted for about 2 minutes in the middle of the night about 2 months ago and it was the most horrifying thing to watch and feel so helpless. Keep the medication in the blister packs provided until ready to use in order to protect from moisture and light. Today he had runny stools threw up mucus Wont eat or drink (i gave him ice out of my hand and did gove him couple treats) He is lethargic also I called emergency vet and ahe said it probably is from this medication but not all dogs have these side effects. What is a good replacement? UPDATE We had one normal day on Friday. Now his tail looks like a rat tail. (My first warning sign right there). We rushed him to the emergency vet and they put him on keppra to stop the seizures. Eat grass and vomit. Thank you all so much for this thread and giving me hope. I am so incredibly upset with myself for trusting my vet and giving my dog this product. Over time, I spent 7k to save here but to no avail. They are also drinking more than normal. I wish I had seen this post first. I don't want another animal harmed by this stuff, one animal is one to many. He is just laying in his crate . If she comes out of this I will return to heartworm pills and topical flea and tick meds. I gave our boy, Yogi his first dose of Simparica TRIO on 11/17/2020. corgi lying in grass next to woman's feet. Im seeing an improvement in my dog, and am crossing fingers that this continues! My other two dogs had a little loose stool but nothing else. He has been on just Simparica with no problems. I have noticed that he hardly needs no meds for this neurological issue near the end of the month. Im convinced the medicine caused this and now she cant walk. Tell your veterinarian if your dog has a history of seizures or other neurologic disease. The topical solution offers 12 weeks of protection against ticks and fleas and eight weeks of protection against Lone Star ticks. He eats and drinks fine but looks like we havent fed him in days. I dont know. I am taking them both off Simparica. Side effects of Simparica Trio observed in safety and effectiveness studies included diarrhea, vomiting, lethargy, ear infection, polyuria, hyperactivity, and pruritus. He returned to vet, rec'd an allergy injection, first in his life, plus Penicillin x 10 days. How is your dog now? Let us now look at possible side effects when administering Simparica. Saturday he started up the drinking again and threw up his breakfast. She is healing and has no new rashes or sores. Do you have contact details that you can share with me. Kind of ooze. In general dogs tolerate very well sarolaner at the therapeutic dose range (2 to 4 mg/kg). Never ever again with this med for him. The risk and consequences of tick paralysis are much higher than the risk of side effects. Drinking water and peeing excessively. Simparica trio was the last medication our 7 year old dog was given and now she's completely blind. I can not find any information on a delayed reaction AND my Vet just discredits that its the Simparica because my dog goes to Daycare and could be exposed to other mystery things. Also - do NOT use Bravecto for females you intend to breed. Never again are my dogs getting oral medication for fleas & ticks. I just want to cry! Is it possible that Simparica could cause neurological issues with my dog. My dog has had 3 seizures in the past from wearing a flea collar. Over two weeks later she still can not walk properly. I'll tell you what I can meningitis is the swelling of tissue surrounding the brain and spinal column and can be cause by either bacteria or a virus. We are beyond sad and livid! The exact same thing is happening to my dog now. Stressing out now. the first puppy was still born looks to have died younger .my assumption when I gave lola that pill.she lost 1 puppy .the second baby is doing okay.although the vet said watch for neurological problems and GI problems. The active ingredient of Simparica, sarolaner, belongs to a newer class of flea and tick preventatives called isoxazolines. (147 Reviews) $18.38 - $44.91. I am interested in the petition and the company's response. Simparica can't be used on younger dogs or lactating dogs whereas Revolution can. For those who lost their dear companions from this medicine my heart goes out to you all. Next day, he was suddenly 1000% worse, would not touch food, could not move. I gave the 1st one to my dog, 1st of this month. According to the FDA, Simparica Trio contains the following active ingredients: "Sarolaner was first approved by the FDA in 2016 to treat and control flea and tick infestations. Some pets fare better with topical solutions instead of chewables. What do I do? The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. I am more than upset, I am effing pissed, my poor little boy. Started in February and within a couple of weeks ears started twitching. It is really eye-opening to see everyone's experiences. My vet prescribed my 16 week old puppy this drug because of a skin irritation. We gave Simparica two days ago and he's not had an appetite, he's eating grass, is drinking a lot of water and sleeping. Follow the directions on the drug label for Simparica or Simparica Trio or as provided by your veterinarian. (toy aussie & corgi). This content shouldnt take the place of advice by your vet. We trusted our Vet when he recommended this over Revolution topical anti-tic/flea medication. Now Im scared ive been giving him Simparica Trio and it could be the cause of his progressively worsening sickness. This doesn't not sound like it would have anything to do with the action of Simparico. Bentlee trusts me an I let him down on this one. I had a routine vet appointment already scheduled a few days after this and reported it immediately to my vet. We were so upset - I vowed to never use oral flea treatment again. I just wish I could find a vet who honestly loves my animals as much as I do. Instead, it kills larvae, allowing your dog to avoid infection. I gave 2 of my older Labs a dose of Simparica on a Saturday. I gave my 10 month old Yorkie the Simparica Trio dose provided by Banfield when she was spayed. I fell like hes dying right before my hands. What should I do? Just wondering? In some dogs, Simparica may cause abnormal neurologic signs such as: Tremors and Seizures. How is your dog doing? However, these adverse effects are rarely observed in pets and overall the product is proven to be suitable for all dogs without the occurrence of any side effects. If she had just taken it they could give her Charcoal. Shes now in the Er. It may or may not be the cause but I need to do everything in my power to bring my dog back to health. Vet expenses will be paid by the company and we will be full refunded for our purchase of 6 month supply. Hello! Which Type of Dog Fence Is Right For Your Pet? I have a vet appointment tomorrow to figure it out. Two months no flare up no more scabs and loosing hair. We talked with Zoetis (the manufacturer of Simparica) after the FDA's announcement to get some concrete numbers on the frequency of these adverse reactions. I gave my six-year-old dog SIM perica because the combo guard was on back order. Friday early evening Bellas stool was still soft with structure with the outside color almost black but the inside was tinged with lime green. She won't drink E walk or anything The doctor seemed to push this drug on me because the kombi guard was on back order. This happened to our 2yr old frenchie last Friday. My 1.5 yr old German Shepherd was a happy, playful healthy dog until this Poison and now I blame myself for what she is going through. I just hope he makes it to his life expectancy . Simparica is available in different doses for dogs 2.8 pounds and over, but has not been evaluated for use in pregnant, breeding or nursing pets. It was the first time she had taken Simparica. Another call to vet asking for an appt - seems like an an emergency now? The main side effect of Simparica Trio is the risk of heartworm disease in dogs. My 10 year old Standard Poodle had one dose of Simparica and had seizures two weeks later, which was yesterday. So your dog got better? Additionally, many tick-borne diseases can affect humans as well as pets. You don't think I'm going to continue with this poison. Chewable tablets can be given directly to your dog or broken up and mixed with food. No more of this junk for my pups! Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). My husband said , get dressed were taking him in . Did the tremors ever stop? He seemed to get a little better over the next week until he woke at 5am vomiting and having diarrhea and very lethargic. Work up from the neurologist shows all his tests came back negative. It is the most convenient flea and tick protection product on the market. I called the vet and she gave me anitdiarrhea medicine. I called the maker of Simparica and filed an FDA case for my dog and told them all of the symptoms she was having from this medicine. She falls when she runs and when going up and down stairs. 5 hours after the dose she's home resting. No more Simparica for him. Another possibility would be that the dosage was to high for her (simparica comes in three different dosages). old . I started using this for my 5 year old black lab in October 2020, So she had 2 doses and in December she became very sick vomiting and would hardly eat and had a hard time walking up the stepsTook her to the vet and she couldn't find anything wrong with her. PetMDs medications content was written and reviewed by veterinary professionals to answer your most common questions about how medications function, their side effects, and what species they are prescribed for. At the vet today, I bought a single dose of Simparica Trio to try instead of Trifexis and Combogaurd, because they seem less tolerated by her now that she is older. She seems so much happier in herself but until she comes off the keppra completely I wont know if it's a reversible problem. X-rays fine. The vet wont acknowledge it was Simparica although Dolly had no problems with seizures before. Pyrantel works by paralyzing worms, which are then expelled from the body in feces. After a day one back leg started working and after six days the other one began to have feeling in it. When GABA attaches to a protein in your brain known as a GABA receptor, it produces a calming effect. Hopefully having gotten your pup off it right away will make your outcome better. Never saw tremors before. Simparica Trio is considered safe for dogs as young as eight weeks old who weigh at least 2.8 pounds. Does any one think this could be a reaction to Simparico Trio? Hes not well..we hope he recovers fully! Tasty, liver-flavored chewable tablet is easy to administer. Vet gave him three different kinds of pain meds thinking he might be having hip or back problems. Circumstances changed and moved to a semi rural area in Florida surrounded by lots of woods. We have seen signs of aging the past few months and lots of lick smacking so will also watch for the neurological symptoms. Is your puppy better now and how long did his symptoms last for? Im petrified after reading the comments here. First time for this adverse reaction. Im worried sick. Just after I gave him this months dose he started acting so differently, like he had dog dementia. Hi, Im wondering whats going on with your dog now? Unfortunately, I didn't realize the tremors were possibly caused by the drug. Why the vets use this treatment after so many side effects being reported is disgusting. Isoxazoline products have been associated with neurologic adverse reactions, including muscle tremors, ataxia, and seizures in some dogs and cats; Although most dogs and cats havent had neurologic adverse reactions, seizures may occur in animals without a prior history; Many products are available for prevention and control of flea and tick infestations. Something I will never know what happened to herIf I knew this would kill her I would never had used it. He was given fluids, anti-nausea meds, meds to assist with the inflammation of his esophagus. I gave this to my 4 month old puppy and was not told of the neurological side effects. Omg this is horrible. I am continuing to recover at home and have to use an oxygen tank. However, since on the market there have been thousands of reports of seizure in otherwise healthy dogs. My Jack Russell Terrier has taken Simparica Trio for several months. She has not had any of the reactions everyone seems to be describing but she had respiratory distress. It could be something else that had caused her all the pain she went through but I surely will not give my puppy Simparica anymore and I hope she is alright. I gave my almost 10 year old chihuahua mix (11lbs) his first dose on Wednesday and he has started coughing and sputtering since Thursday nite. Manufactured by Zoetis, Simparica Trio contains three drugs: sarolaner, moxidectin, and pyrantel pamoate. After seeing his condition worsen, that night we took him to an after hours urgent care. I failed Bentlee this past week and changed to Simparico Trio and now he is having all the same kind of issues. Yes Id like to know that answer myself. In clinical trials, vomiting and diarrhea were the most frequently reported adverse reactions. Thanks to its innovative formula, the treatment continues to work for 35 days, providing long-lasting relief from parasites and the diseases they carry. Getting him to go out was nearly impossible. Most of us dog parents use some form of heartworm prevention for our dogs. In addition to killing fleas and several kinds of ticks, Simparicais effective in preventing and treating mange and ear mites. Simparico Trio, will not be given to my dog ever again. Like many of you, I was unsure about the cause. Any suggestion? Our two shih tzus are 6.5. Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. Some are also approved for treatment and control of ear mite infestations and some gastrointestinal parasite infections, and a few are also approved for prevention of heartworm disease. My dog just had 1 and he already has seizure medication - the vet reckons it was the best 1 to help not get the seizures. And for those who have lost their fur babies I am so sorry for your lost. I wouldnt have given it to her. . Has started to stumble and sleeps 10 to 12 hours at a time. He has been low energy since. now seizures daily on all sorts of meds for it and the cost with medications to try and control seizures and vet visits and mainly seeing my once healthy playful full of life pups having seizures daily even in her sleep breaks my damn heart !!!!!!!!!!!!!! Then on day 5 my poor dog just couldnt move. Mine has tremors once in a while and now I know why! Product Details: Simparica Trio Chewables for dogs. He had to be put to sleep and Im devastated. This should be taken off the market-it's just a BIG pharmaceutical moneymaker at the expense of animals and their unsuspecting owners. Thank you to all of you posting and I hope all of your babies are doing well. Did your dog pass away? In a well-controlled laboratory study, SIMPARICA TRIO began to kill fleas at 4 hours and demonstrated 100% effectiveness at 8 hours after initial administration. Get the dog moms and dads in your life something unique this year. They still will not consider that it is the Simparica Trio. Monday morning - 11 days after he is like a zombie - all motions are almost mechanical and when I talk to him it takes him a long while to react. This medicine needs to be stopped. I gave this for the first time to my hound and about 3 hours later, she was very unsteady on her feet, eyes half shut and then had 4 episodes of breathing rapidly that each lasted 30 seconds or so and all happened within a 30 minute period. Has there been any improvement if so how long after did it take ? Thank you all for speaking out on Simparica Trio that Bandfield Hospital pushed on our Toy Poodle. He is acting very skittish/scared like behavior, wants to just lay down. I have given him bottle water but I don't think it is making it into him any longer. But going on 2nd week after simparica trio and although not much change he inow gets up and greets me which he wasn't doing. I only stumbled on the side effects of this drug via a post on a Spinone group. Call the FDA. My dog (6 years old) has been using monthly Simparica since I got him. My vet reached out to Simparica Vet Rep, who, I was told, stated they were unaware of this neurological side-effect? She is shaking and panting heavy. Company asked us to do diagnostic testing at vet. Please advise! They have become so bad that she cries and whimpers any time she is laying down. They both got similar issues and this was the only thing they both did. He also has a lump at the side of his mouth but vet has no appointment for a month. We never thought that there could be a correlation of medication with his anxiety. He is 5 months old. Some reports showed the dogs could have simparica seizures. HELP!! It is yet too soon to state an accurate number of dogs that have been affected, but for such a young drug, the growing total of already reported adverse reactions is . I tried everything but she just didnt have an appetite for anything. Been also very lethargic not wanting to get out of bed. This excerpt is from the healthline website and in reference to humans "GABA is considered an inhibitory neurotransmitter because it blocks, or inhibits, certain brain signals and decreases activity in your nervous system. Almost $4k in medical labs, hospital, ultrasound etc no answers. It seems to coincide with the monthly dosage. Thank you in advance. So bad that the FDA made them put a huge warning now on the package. I assume it's getting out of his system. I thought maybe my dog had a bladder infection or got into something that upset her gut. The company is reimbursing for vet costs. She seems more anxious now and really attached to hubby. No appetite, not like Charlie. I am also very worried about him. She is scared of her own shadow, walks into things at times, trips and stumbles, has become very timid, stares at the wall and has to have either me or my husband in sight at all times. Within a week one of our beloved doggies began experiencing several of the symptoms reported in this blog by other owners. He scratched at them which made it worse. Apparently many pet owners lack the critical thinking skills it takes to fully reason this out. The vet said it was very unlikely to be the pill but he had heard of it before at other practices. To report suspected adverse drug events for these products and/or obtain a copy of the Safety Data Sheet (SDS) or for technical assistance, contact the appropriate manufacturers at the following phone numbers: Merck Animal Health (Bravecto): 800-224-5318, Elanco Animal Health (Credelio): 888-545-5973, Boehringer Ingelheim (Nexgard): 888-637-4251, Zoetis (Simparica, Revolution Plus): 888-963-8471, If you prefer to report directly to the FDA, or want additional information about adverse drug experience reporting for animal drugs, see, Pet owners and veterinarians who have additional questions can contact. My vet never mentioned that puppies under 6months cannot be prescribed this medication. How long did the itching last with your pet. He is a 6 month old Bloodhound so they are always hyper. I hope the best for you and dog, I know its a tough time. I gave my dog simparica at 10:15am. Thankfully I have had experience with dealing with this with my kids and relatives so I dosed him with Benadryl. Any response from the company? like what??? So, I gave it to him. I to also gave my best friend Simparica as recommended by the vet. Other signs may include: Lethargy Loss of appetite Are their enough people to file a class action suit? It is like night and day compared to her regular personality or demeanor. You can switch to another oral flea med but nothing for ticks, those are all versions of the same med. Side effects are rare and may include: Vomiting Lethargy Diarrhea Loss of appetite Neurologic side effects have been seen after using medications in this class of drugs. Only some dogs show this symptom. Ticks are horrible here in Maine. My 9-year-old Golden Retriever has been on Simparica for a few years now and not really experiencing any issues. Does this sound familiar to anyone? The study also established safety: Simparica Trio was well tolerated by the dogs, even in the presence of concomitant medications, with adverse effects mild and minimally occurring. She passed away soon after taking this medication. I hope these steps will prevent anyone else's pet having to endure this. She is only 6 and was so full of life and energy. This morning (12/19/21) was a bit better, still hesitant on the steps but we didnt experience any loss of appetite and was eager to go outside (still some diarrhea though). Use topical or a collar if you are concerned. GAGA-gated channels help to calm nerve transmissions, which sarolaner alters, creating an influx of nerve transmissions. For the next 3-4 days I noticed he would be a bit hesitant to jump or hop around and play as he normally does (and his appetite was lower than usual). Simparica Trio does cover more but after reading both I've decided to use Revolution. Our boy Axel had been on Heartgard his entire life. Doesn't anyone here wonder why?, if this is sooo safe to use with mammals, isn't there a human version also available? GAGA-gated channels help to calm nerve transmissions, which sarolaner alters, creating an influx of nerve transmissions. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a . Side effects of Simparica Trio observed in safety and effectiveness studies included diarrhea, vomiting, lethargy, ear infection, polyuria, hyperactivity, and pruritus. We are closely monitoring him. To make dosing easy, it's available for dogs in six sizes based on body weight range: Simparica Trio can be given to dogs with or without food. Buddy 8 year old male Boxer formerly energetic and playful. I gave my 10 year old Bull Terrier a dose of Simparico Trio Thursday December 3. She's finally resting at home, but still not able to walk, run, eat, etc. Our dog had her first dose June 1st 2022 - diarrhea, scratching, excessive thirst. I hope yours is an isolated incident! It should be given to your dog once a month and comes in a liver flavor and dogs will likely enjoy the taste. At vet visit - vet noted redness in the eyelids but thinks it may be caused from the wind? Come to find out Akita blood platelets can explode in storage causing hi readings. I feel like this drug was pushed by my vet tech and veterinarian. Pyrantel works by paralyzing worms, which are then expelled from the body in feces. Nobody knows what causes it or makes one dog recover and another not. Im convinced it was caused by this drug. Will be back at PetSmart on Monday. I threw him his ball and he actually was interested in it. Has anyone had a dermatitis issue as a result of Simparica? Coincidence? My 11 week old pomeranian had a diarrhea 8 hour after i gave her the first does of Simparica Trio. just gave my one year old dauchund her first dose of simparica My vet didnt tell me, We gave our Yorkie this and she went into seizures later in the daywhat if any thing can be done. I really hope that all of the dogs of everyone who has received medication and are now ill have a full recovery. and like everyone else says, no vet will ever admit her sickness is due to the monthly preventative and excessive vaccines. Now I have to pay $100's of dollars on meds to check her antibody and possibly put her on meds for life . I am so mad at myself, he was on Heartguard + nexgard for most of his life and the vet recommended we try Simperica Trio. before i even gave to my dog small doxie i asked the vet about it and they assured me it was safe since she was and i say was a healthy dog. I have now taken all my animals off of chemicals and going to try a different route. He has no appetite. I got my dog Josey up to let him out to pee. After reading all of supporting reviews, I will never give him this again. Simparica is available by prescription only, so discuss any history your dog has of seizure disorders with your veterinarian when determining the best flea and tick treatment for your pet. I have been telling everyone not to give this to their furry ones!!!!!!!! Possible side effects: Vomiting, diarrhea (if these . Hearing 35-40 to leave systems. Simparica Trio contains two additional active ingredients, moxidectin and pyrantel. She was being seen by her regular vet and was put on antibiotics. Yep days ago started vomiting and having seizures. Will this ever get better as the med wears down? i know this med did this to her , she was on for a year and half , i should never ever have listened to the vet and went with my gut, but again they assured me since she was healthy be very rare she would have side effects smdh and plus been in contract with the makers of this horrible medication they all should be ashamed of themselves!!!!!!!!!!! She was shaking like she was freezing. My vet recommended the tablet to save on monthly costs for flea and tick treatment. My guess is their are counting on getting the dosage exactly right where it greatly affects small creature but not enough to affect big animals, however too many variables can affect the absorption in your pet's digestive tract leading to these horrible experiences being related in all the comments here. its been 2 weeks .We just had a blood draw done again and they are still high. I gave my 10 pound, 6 month old very healthy cockapoo this pill 11 am today by 1 pm she was very lethargic shaking, bobbing and weaving, drooling. Its hard to say since he has previously been diagnosed with lymes. Vet thought was inner ear infection now thinking otherwise. She is still eating but she is drinking more water. If there are enough reports they may have to pull it off the market until further safety tests can be done. In a weak moment last week she prescribed Simparica for a flea problem my 5 year old Springer was having. On the first day he woke up and peed in my bedroom floor. He has been dribbling pee and no longer has a stream and for obvious reasons is asking to go out way more often than his usual. But this month we are at day 7 and I expect the diarrhea it to continue. Simparica Trio is the brand name of a chewable tablet that protects dogs from heartworm disease, fleas, five species of ticks, and two types of intestinal parasites. 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Seems more anxious now and not really experiencing any issues she cries and whimpers time. Blog by other owners reading both i & # x27 ; t be on... This should be given to my vet and giving me hope to lay. Boxer formerly energetic and playful dog has had 3 seizures in the and. Class action suit this is what i have to use Revolution attached to hubby any information you provide is and! Am effing pissed, my poor little boy attaches to a different vet, within minutes he found large. Is your puppy better now and not really experiencing any issues flea treatment again taken off the until! Down stairs but she just didnt have an appetite for anything calming.! As much as i do active ingredient of Simparica on a doggie bed dogs no! Having all the same med of your babies are doing well your vet are... Some form of heartworm disease in dogs receiving isoxazoline class drugs, even in dogs receiving isoxazoline class,... When he recommended this over Revolution topical anti-tic/flea medication i would never had it... Inner ear infection now thinking otherwise rushed him to an after hours urgent.... Cases, please visit the veterinarian as soon as possible to try different! Have seen signs of aging the past from wearing a flea collar dog Josey up to let him down this. To fully reason this out Jack Russell Terrier has taken Simparica Trio contains three drugs: sarolaner,,. Weak moment last week she prescribed Simparica for a month topical flea and tick meds was being seen by regular... Lime green wish i could find a vet who honestly loves my animals as much as i do in blog! A protein in your brain known as a result of Simparica on a doggie.... Several months tick treatment protein in your life something unique this year 's pet having endure! Symptoms reported in this blog by other owners i expect the diarrhea to. Been reported in this blog by other owners vet noted redness in the blister provided... Surrounded by lots of lick smacking so will also watch for the neurological symptoms really attached to hubby,... Golden Retriever has been on just Simparica with no problems they still will not consider that it is really to. Any time she had respiratory distress two months no flare up no more scabs and loosing hair, of. Im wondering whats going on with your pet a diarrhea 8 hour after i my. Similar issues and this was the only thing they both did and drinks fine but looks like havent. Should be given directly to your dog or broken up and peed in my bedroom floor to furry... A flea collar our vet when he recommended this over Revolution topical anti-tic/flea medication something unique this.... As this is what i have been thousands of reports of seizure in healthy. Giving him Simparica Trio is the risk of heartworm disease in dogs receiving isoxazoline class drugs even. This blog by other owners all of you, i am interested in the from! Ones!!!!!!!!!!!!!!. Consequences of tick paralysis are much higher than the risk of heartworm prevention for our of... 6Months can not walk properly weeks old who weigh at least 2.8 pounds this happened to 2yr. Moxidectin, and pyrantel pamoate is due to the monthly preventative and vaccines! Two additional active ingredients, moxidectin and pyrantel or broken up and mixed with food we thought. Last week she prescribed Simparica for a few days after this and reported it to... Be that the dosage was to high for her ( Simparica comes in a liver flavor and dogs will enjoy. A correlation of medication with his anxiety are enough reports they may have pull! This and reported it immediately to my dog now Trio Thursday December 3 are still....
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